VUMC FRIM Core (Free Radicals in Medicine)

Overview of Services

The Free Radicals in Medicine Core, FRIMCORE, provides site-specific, selective and reliable measurements of reactive oxygen species (ROS) such as superoxide radical (O2•), hydrogen peroxide (H2O2), nitric oxide (NO•) and peroxynitrite (ONOO−) and various free radical intermediates in cells and tissue for investigators at the Vanderbilt Campus and beyond. Major resources are the Electron Spin Resonance spectrometer (ESR) and HPLC system for quantitative superoxide measurements using spin traps, spin probes, fluorescent probes dihydroethidium and MitoSOX. We are located on the fifth floor of the Preston Research Building. The facility is available to all Vanderbilt faculty and other interested parties. We provide assistance with ROS measurements and consultations for ROS-related studies.


Sergey Dikalov, Ph.D.

For general questions, email

Location and hours of operation



PRB 554 

Links and Resources