VUMC Functional Genomics Core

Overview of Services

The FGI Core will provide pooled CRISPR screening and primary human hematopoietic cells.  Forward genetic screens have been foundational in lower model systems but challenging in primary human or mouse cells.  CRISPR technology now allows highly efficient pooled forward genetic screening.  The Functional Genomics & Immunology core is based on technology developed in the Rathmell lab and collections of deidentified human peripheral blood by the Vanderbilt Center for Immunobiology.  The core will generate and manage pooled gRNA screening libraries for CRISPR and perform screening assays and analyses.  The core will also collect and distribute deidentified primary healthy donor peripheral blood samples from leukapheresis.  These resources will provide essential immunological research material from clinical patients and translational animal models; to facilitate the application of functional genomics pooled CRISPR screening to identify gene targets; and promote collaboration among research groups with different interests and expertise.


Jeff Rathmell, Ph.D., Core Scientific Director

Location and hours of operation

Hours Location

Monday - Friday
8:00am to 4:00pm        

  MRB3 U2216  

Links and Resources

VUMC Functional Genomics Core website:


Billing Number Activation

 VUMC Investigators with VUMC center numbers:
  All VUMC billing numbers are activated in iLab via a nightly feed from Workday. Grant Worktags are auto-assigned to the PI's lab group. All other funds (Cost Centers, Gift or Program Worktags) must be claimed within the PI's Lab Group.
 VU Investigators with VU CoA or POET numbers:
  VU users will manage the VU billing numbers via the webform on the VUMC Office of Research website
 Vanderbilt Investigators with VA (Veteran Affairs) funding: 
  Contact the VUMC Office of Research at to request access to your VA funding.  All investigators with VA funding are assigned a VA billing number (999999xxxx). The VUMC Office of Research manages VA billing numbers in coordination with the VA Research Administration.