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VUMC Eicosanoid Core

Overview of Services

The Eicosanoid Core Laboratory (ECL) at Vanderbilt University Medical Center is especially designed for the analysis of oxidized lipid mediators. It one of the few laboratories in the world equipped for measuring many different oxidized derivatives of arachidonic acid including isoprostanes, prostaglandins, leukotrienes, and their respective metabolites.

The ECL was established in 1988 to provide a central laboratory for the analysis of eicosanoids and their metabolites for investigators at Vanderbilt University. In the mid-1990s, the facility broadened its scope such that investigators, not only at Vanderbilt, but throughout the U.S. and the world, could utilize the laboratory for lipid mediator analysis.  All of the assays performed are validated highly precise, accurate, and sensitive mass spectrometric (MS) assays, many of which were developed by Core staff.  The Eicosanoid Core Laboratory has several mass spectrometers, including an Agilent 6890/5973 gas chromatography/mass spectrometer, a Waters Acquity Classic UPLC fitted to a SCIEX 6500+ QTrap mass spectrometer with SelexION+ technology, and a Waters Acquity I Class UPLC fitted to a Waters Xevo TQ-S Micro triple quadrupole mass spectrometer. 

The ECL is located in the Division of Clinical Pharmacology in the Preston Research Building, rooms 561, 562, and 553.  Personnel in the ECL have extensive experience in the analysis of lipid mediators and routinely perform thousands of these analyses per year.  Dr. Ginger Milne has been director of the ECL since 2008.

Leadership

Director:  Ginger Milne, Ph.D.
Lab Manager: Stephanie Sanchez

For general questions, please email Ginger Milne at ginger.milne@vumc.org or Stephanie Sanchez at stephanie.sanchez@vumc.org

Location and hours of operation

Hours Location

8:00am to 4:00pm   
Monday-Friday

PRB 561, 562, & 553. 

Links and Resources

  1. https://labnodes.vanderbilt.edu/community/profile/id/1131
  2. Acknowledgements:  https://labnodes.vanderbilt.edu/resource/view/id/10709/community_id/1131
  3. iLab User Guides & FAQs