Overview of Services The Metabolic Physiology Shared Resource (MPSR) (Kevin Niswender, MD, Ph.D., Director) assists investigators wishing to address hypotheses related to diabetes and metabolism. The Rat Metabolic Physiology Core (RMPC) is a section of the MPSR that provides novel techniques to better understand specifically rat models of diabetes and its complications.
The RMPC offers a variety of services including:
Chronic artery &/or vein cannulation Chronic ileal vein cannulation Chronic portal vein cannulation Insulin clamps Pancreatic clamps and more...
Our Goals
broaden the scope of techniques available to investigators
standardize key methodologies
expedite the completion of research
*The Vanderbilt University Medical Center (VUMC) Metabolic Physiology Shared Resource Core (MPSR) is supported by Diabetes Research Training Center (DRTC) NIH grant DK020593. Please acknowledge this in your publications*
Leadership Kevin Niswender, MD, PhD, Core Director
Tiffany Farmer, MS, Lab Manager
Alisa Escue, Core Administrator
Contact Us: kevin.niswender@vumc.org OR t.farmer@vumc.org
Location and hours of operation
Hours Location
8 am - 4 pm, Monday - Friday
807 LH
Links and Resources
https://www.vumc.org/mpsr
Search available services:
View: by category
alphabetically
Name
Description
Price
Carotid Artery + Jugular Vein
Double catheter
Typically used for: Insulin clamp, Hyperglycemic clamp, DMPK, Tolerance test
Inquire
Carotid Artery + Jugular Vein + Ileal Vein
Triple catheter
Typically used for: Pancreatic clamp, Insulin clamp
Inquire
Carotid Artery + Jugular Vein + Ileal Vein + Portal Vein
4 catheter
Typically used for pancreatic clamp
Inquire
Charles River - Rat
Each
Pricing is determined by Charles River catalog based on age/size, species, and gender
Inquire
Cisterna Magna
Chronic single catheter placed in cisterna magna for CSF sampling over time
Inquire
CLAMS Energy Expenditure (per rat/day)
Comprehensive Laboratory Animal Monitoring System (CLAMS)
Energy Expenditure, price includes 5008 meal. Alternative diet charged separately.
Inquire
Glucose Tolerance Test (GTT)
Blood sampled via arterial catheter
Oral, Intravenous, or Intraperitoneal
* Price does not include cost of surgery, injection, or personnel time.
Inquire
Insulin Clamp
Blood sampled via arterial catheter
Peripheral infusion of Insulin
Peripheral infusion of Glucose to maintain desired concentration
(Optional) Peripheral infusion of 3-3H-Glucose to measure endogenous glucose production
(Optional) Bolus of 14C-2-Deoxyglucose to measure muscle glucose uptake
*Price of surgery not included
Inquire
Insulin Tolerance Test (ITT)
Blood sampled via arterial catheter
Oral, Intravenous, or Intraperitoneal
* Price includes supplies. Does not include cost of surgery, injection, or personnel time.
Inquire
Osmotic Pump &/or Pellet
Subcutaneous implant
Pump is to be prepared by investigator
Inquire
Pancreatic Clamp
Blood sampled via arterial &/or portal vein catheter
Peripheral infusion of somatostation to inhibit endogenous production of insulin & glucagon
Intraportal infusion of insulin and glucagon at set concentrations
Peripheral infusion of glucose to maintain desired concentration
(Optional) Peripheral infusion of 3-3H-Glucose to measure endogenous glucose production
(Optional) Bolus of 14C2DG to measure muscle glucose uptake
*Price of surgery not included
Inquire
Personnel (per day)
Per day
Inquire
Personnel (per hour)
Per hour
Inquire
Rat DMPK Study
Blood sampled from arterial catheter
Administration of substrate(s) by single infusion or bolus via venous catheter, oral gavage, IP injection, or SC injection
* Price does not include cost of surgery, injection, or extra personnel time.
Inquire
Single Vessel Catheter
Carotid artery, Femoral artery, Jugular vein, or Femoral vein
Inquire
Tissue: 14C-2-DeOxyglucose
Per rat
Inquire
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Procedures - Surgery (6)
Name
Description
Price
Single Vessel Catheter
Carotid artery, Femoral artery, Jugular vein, or Femoral vein
Inquire
Carotid Artery + Jugular Vein
Double catheter
Typically used for: Insulin clamp, Hyperglycemic clamp, DMPK, Tolerance test
Inquire
Carotid Artery + Jugular Vein + Ileal Vein
Triple catheter
Typically used for: Pancreatic clamp, Insulin clamp
Inquire
Carotid Artery + Jugular Vein + Ileal Vein + Portal Vein
4 catheter
Typically used for pancreatic clamp
Inquire
Osmotic Pump &/or Pellet
Subcutaneous implant
Pump is to be prepared by investigator
Inquire
Cisterna Magna
Chronic single catheter placed in cisterna magna for CSF sampling over time
Inquire
▼
►
Procedures - Study (6)
Name
Description
Price
Insulin Clamp
Blood sampled via arterial catheter
Peripheral infusion of Insulin
Peripheral infusion of Glucose to maintain desired concentration
(Optional) Peripheral infusion of 3-3H-Glucose to measure endogenous glucose production
(Optional) Bolus of 14C-2-Deoxyglucose to measure muscle glucose uptake
*Price of surgery not included
Inquire
Pancreatic Clamp
Blood sampled via arterial &/or portal vein catheter
Peripheral infusion of somatostation to inhibit endogenous production of insulin & glucagon
Intraportal infusion of insulin and glucagon at set concentrations
Peripheral infusion of glucose to maintain desired concentration
(Optional) Peripheral infusion of 3-3H-Glucose to measure endogenous glucose production
(Optional) Bolus of 14C2DG to measure muscle glucose uptake
*Price of surgery not included
Inquire
Rat DMPK Study
Blood sampled from arterial catheter
Administration of substrate(s) by single infusion or bolus via venous catheter, oral gavage, IP injection, or SC injection
* Price does not include cost of surgery, injection, or extra personnel time.
Inquire
Glucose Tolerance Test (GTT)
Blood sampled via arterial catheter
Oral, Intravenous, or Intraperitoneal
* Price does not include cost of surgery, injection, or personnel time.
Inquire
Insulin Tolerance Test (ITT)
Blood sampled via arterial catheter
Oral, Intravenous, or Intraperitoneal
* Price includes supplies. Does not include cost of surgery, injection, or personnel time.
Inquire
CLAMS Energy Expenditure (per rat/day)
Comprehensive Laboratory Animal Monitoring System (CLAMS)
Energy Expenditure, price includes 5008 meal. Alternative diet charged separately.
Inquire
▼
►
Personnel Time (2)
Name
Description
Price
Personnel (per day)
Per day
Inquire
Personnel (per hour)
Per hour
Inquire
▼
►
Analysis (1)
Name
Description
Price
Tissue: 14C-2-DeOxyglucose
Per rat
Inquire
▼
►
Supplies - Animals (1)
Name
Description
Price
Charles River - Rat
Each
Pricing is determined by Charles River catalog based on age/size, species, and gender
Inquire
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