VUMC Cardiovascular Translational and Clinical Research (CLTCR)

Overview of Services

 

The Cardiology Core Laboratory for Translational and Clinical Research (CLTCR) was established in 2009. The main function of the CLTCR is to facilitate investigations on clinical outcome and pharmacogenomic research on cardiovascular diseases and to provide resource support for cardiovascular translational and clinical research. Our Core Lab has a well-established infrastructure and standard operating procedure (SOP) for biobanking, and it has become a fundamental resource for establishing and maintaining a variety of cardiovascular biorepositories. These include serum, plasma, DNA, RNA, human heart tissue samples and Induced pluripotent stem cells (iPSC) lines from the Vanderbilt Heart and Vascular Institute (VHVI). Our lab has been the key laboratory for blood and DNA sample processing for cardiovascular clinical trials conducted at the VHVI, and has been the central biorepository for a number of large multi-center clinical trials.

 

The CLTCR offers experimental services oriented towards development of new biomarkers and detection/identification of genetic mutations/variations for diagnostic test or drug response. These include, but are not limited to, DNA and RNA extractions, SNP detection, real-time RT-PCR on target gene expression, assessment and validation of biomarkers using different platforms, such as ELISA, Luminex technology and Roche Cobas e411.  We are committed to developing and applying new technologies for biomarker testing, and to providing our services with the highest quality and integrity.

 

Resources:

  • VHVI  Heart Registry/Biorepository.  Plasma, Serum and DNA available for research.
  • Human Heart Tissue Bank, heart tissues donated by heart transplant patient for research use.
  • Surgical waste cardiovascular tissue samples donated by patient for research use.
  • Biomarker testing using Luminex technology.
  • Clinical Trial sample processing and biobanking.
  • To request VHVI Biorepository samples, please contact us at core.heart@vanderbilt.edu.

Leadership

                                                                                                          

       Yan Ru Su, M.D.                                                   Kelsey Tomasek                                                   Carlos Fulmer

            Director                                                               Coordinator                                                 Core Research Asisstant I

Location and hours of operation

Hours Location

Monday - Friday, 8AM to 5PM    

332 PRB
2220 Pierce Avenue
Nashville, TN 37232-6300

 

Links and Resources

Website Coming Soon