About

VUMC Cardiovascular Translational and Clinical Research (CLTCR)

Overview of Services

 

The Cardiology Core Laboratory for Translational and Clinical Research (CLTCR) was established in 2009. The main function of the CLTCR is to facilitate investigations on clinical outcome and pharmacogenomic research on cardiovascular diseases and to provide resource support for cardiovascular translational and clinical research. Our Core Lab has a well-established infrastructure and standard operating procedure (SOP) for biobanking, and it has become a fundamental resource for establishing and maintaining a variety of cardiovascular biorepositories. These include serum, plasma, DNA, RNA, human heart tissue samples and Induced pluripotent stem cells (iPSC) lines from the Vanderbilt Heart and Vascular Institute (VHVI). Our lab has been the key laboratory for blood and DNA sample processing for cardiovascular clinical trials conducted at the VHVI, and has been the central biorepository for a number of large multi-center clinical trials.

 

The CLTCR offers experimental services oriented towards development of new biomarkers and detection/identification of genetic mutations/variations for diagnostic test or drug response. These include, but are not limited to, DNA and RNA extractions, SNP detection, real-time RT-PCR on target gene expression, assessment and validation of biomarkers using different platforms, such as ELISA, Luminex technology and Roche Cobas e411.  We are committed to developing and applying new technologies for biomarker testing, and to providing our services with the highest quality and integrity.

 

Resources:

  • Accredited Biorepository by the College of American Pathologists (CAP)
  • VHVI Heart Registry/Biorepository - Plasma, Serum and DNA available for research.
  • Human Heart Tissue Bank, heart tissues donated by heart transplant patient for research use.
  • Surgical waste cardiovascular tissue samples donated by patient for research use.
  • Biomarker testing using Luminex, Roche, and ELISA technologies.
  • Clinical Trial sample processing and biobanking.
  • To request VHVI Biorepository samples, please contact us at core.heart@vumc.org

Leadership

                                                                                                                                                             Michael Glennon                              

       Yan Ru Su, M.D.                                                   Kelsey Tomasek                                                   Carlos Fulmer                                                      Michael Glennon

            Director                                                               Manager                                                     Core Research Asisstant II                                      Core Research Assistant II

Location and hours of operation

Hours Location

Monday - Friday, 8AM to 5PM    

332 PRB
2220 Pierce Avenue
Nashville, TN 37232-6300

 

Links and Resources

Cardiology Core Lab Website

Cardiology Core Lab Gains CAP Accreditation - VUMC Reporter

 

Billing Number Activation

 VUMC Investigators with VUMC center numbers:
  All VUMC billing numbers are activated in iLab via a nightly feed from Workday. Grant Worktags are auto-assigned to the PI's lab group. All other funds (Cost Centers, Gift or Program Worktags) must be claimed within the PI's Lab Group.
 
 VU Investigators with VU CoA or POET numbers:
  VU users will manage the VU billing numbers via the webform on the VUMC Office of Research website. 
 
 Vanderbilt Investigators with VA (Veteran Affairs) funding: 
  Contact the VUMC Office of Research at VUMCcores@vumc.org to request access to your VA funding.  All investigators with VA funding are assigned a VA billing number (999999xxxx). The VUMC Office of Research manages VA billing numbers in coordination with the VA Research Administration.